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Oral isotretinoin has been used successfully treat to extensive AN.[31] Metformin and rosiglitazone Metformin and rosiglitazone are useful in AN characterized by IR

This latter process occurs by reversible oxidation of a pair of cysteine residues, release of elemental Mercury(0) and subsequent reduction of the oxidized inactive enzyme by NADPH [95,96]

Lin H, Huang H, Yu Y, Chen W, Zhang S, Zhang Y

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