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Description
Secondary metabolites term was first introduced by the Nobel Prize laureate Albrecht Kossel in 1891 and the botanist Friedrich Czapek further created the term secondary modifications in his work related to plant nitrogen metabolism in the 1920s (Henriksen et al., 2022)

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

the sensitivity of detection is low
Zhang B, Cheng Z, Chen J, Zhang X, Liu D, Jiang H, et al