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Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion

Stress-induced Ca 2+ spikes serve as secondary messengers, activating calcium-dependent protein kinases (CDPKs) and calcineurin B-like proteins (CBLs) that regulate stress-responsive gene expression ( 2+ -mediated pathways by stabilizing ATP-dependent pumps and channels, ensuring controlled Ca 2+ fluxes during stress responses

[DOI] [PubMed] [Google Scholar] 234.Wang J.Q., Zhang J., Chen L.P., Cai J., Li Z.J., Zhang Z.G., Zheng Q., Wang Y., Zhou S., Liu Q., et al

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