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This receptor modulation triggers a cascade of intracellular signaling events that ultimately result in the activation of hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol

While MMPs are necessary for wound healing, excess activity can degrade healthy tissue

Finally, the gut microbiome may contribute to NAFLD pathogenesis: an increased intestinal permeability could lead to the entry of endotoxins in portal circulation and activation, through toll-like receptor 4, of Kupffer cells, with consequent inflammation (5053)

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