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Description
KNOCK-IN MUTATION Introduction of a transgene into a precise location in the genome, rather than random integration

In 2007, a disorder with cutaneous findings (multiple caf-au-lait macules and axillary freckling) similar to NF1 was described 4 , although the causative gene ( SPRED1) was different

It encourages fluid loss, which leads to dehydration

Also included are potassium citrate (systemic alkalizer) for optimal osteo support and Type II Collagen to support cartilage
