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[Google Scholar] 22.Seifert O, Holmberg J, Linnarsson BM

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Here's what happens: Just 200 mcg of folic acid overwhelms your DHFR enzyme Unmetabolized folic acid (UMFA) accumulates in your bloodstream UMFA competes with natural folate and blocks methylfolate from binding to FR Your brain's primary folate delivery system gets shut down For pregnancy: Folic acid blocks the FR receptor that delivers folate to both the placenta and your baby's developing brain