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You found animal studies, mechanistic data, even small human trials

Novo has since launched a broad late-stage program for CagriSema, including the Phase III trials REDEFINE 1, which is assessing its efficacy as a weight loss therapy, and REDEFINE 2, designed to include type 2 diabetes patients with excess body weight

doi: 10.18632/aging.202850 [DOI] [PMC free article] [PubMed] [Google Scholar] 33

A person can have arterial stiffness without extensive plaque, plaque without obvious symptoms, or both processes at the same time
