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These neurophysiological shifts were observed in preschoolers with ASD (35 males and 11 females) diagnosed through to DSM-5 and validated with ADOS-2 and ADI-R, with participants screened to exclude neurological syndromes, epilepsy, sensory impairments, gastrointestinal diseases, secial diets, and other major comorbidities

Homocysteine can be degraded not only through the METZ but also through the transsulfuration pathway

This decline was observed in excitatory and inhibitory neurons as well as astrocytes, suggesting a potential link between glial dysfunction and impaired synaptic plasticity

doi: 10.1023/b:pham.0000008047.82334.7d