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It has been observed that insulin resistance reduces mitochondrial respiration [56] and that human umbilical cord mesenchymal stromal cells from patients with GDM have premature senescence phenotypes and mitochondrial dysfunction

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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., 2008)
