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Croat Med J 54(5):419428

Under these circumstances, Nrf2 migrates to the nucleus and activates genes driven by the antioxidant response element (ARE), thereby promoting redox homeostasis
Hyperuricemia is a condition characteristic for a multicellular organism and so the results may not obligatory be related to real pathophysiological conditions

It was well known that, under physiological conditions, the NRF2/HO-1 axis is essential for resistance to oxidative stress, and upregulation of this axis significantly suppresses the expression of NLRP3, caspase-1, and ASC, inhibits inflammasome formation, blocks GSDMD activation, and prevents the release of IL-1 and IL-18
