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Eur J Nutr 46:20412 Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco GR, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulon D, Alpert JE, Barbee JG, Zisook S, Fava M (2012) l-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials

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However, despite many published articles using the N-to-B route to target peptides and protein to the CNS, nearly all use liquid formulations like emulsions, suspensions, and sprays, among others, and only a few use formulations in solid-state