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MicroRNAs and Long Non-Coding RNAs Are Epigenetic Regulators of Gene Expression MicroRNAs (miRNAs) are a family of small non-coding RNAs (1925 nucleotides -nts) that can regulate a plethora of biological processes via the modulation of the expression of target genes at the post- transcriptional level (21)

Changes in genetics encompass MET exon 14 skipping mutations (METex14), amplification of MET genes, increased c-MET protein levels, structural domain mutations in MET kinase, and fusion of MET genes [22]

1 When released, GLP-1 activates its receptor, GLP-1R, in the pancreatic islet cells, provoking a myriad of metabolic changes characterized by insulin secretion and appetite suppression