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[DOI] [PubMed] [Google Scholar] 103.Khoury A, Pagan KA, Farland MZ

632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway

Common findings include mild fluid retention, occasional injection site reactions, and possible for hypoglycemia at higher doses

S., Gerecht S., Shieh H