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Elle peut se manifester notamment par des dmangeaisons, une urticaire, un eczma, une rougeur de la peau, un dme (gonflement), pouvant tre svres, un dme gnralis, un brusque gonflement du visage et du cou (dme de Quincke), voire un malaise intense et brutal avec chute de la pression artrielle (choc)

World Journal of Diabetes : Association Between Metformin and Vitamin B12 Deficiency in Patients With Type 2 Diabetes World Journal of Diabetes : Long-Term Metformin Therapy and Vitamin B12 Deficiency: An Association to Bear in Mind Diabetes, Obesity & Metabolism : Metformin-Induced Vitamin B12 Deficiency Can Cause or Worsen Distal Symmetrical, Autonomic and Cardiac Neuropathy in the Patient With Diabetes U.S

This may be if the tophus is on the bottom of the foot, and the person has difficulty walking on it, or on the side of the foot making it hard to wear shoes

Usually, this happens due to damage to the blood vessels that may occur during the blood draw procedure