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GCLC: Glutamatecysteine ligase catalytic subunit

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doi: 10.3389/fphar.2023.1059343 Received 01 October 2022 Accepted 30 May 2023 Published 19 July 2023 Volume 14 - 2023 Edited by Maria Letizia Manca, University of Cagliari, Italy Reviewed by Dilpreet Singh, Indo-Soviet Friendship College of Pharmacy, India Priyanka Maurya, Babu Banarsi Das Northern India Institute of Technology, India Sudheesh K

While Nrf2 and JAK2/STAT3 are indeed activated as protective responses during MIRI, the overwhelming and dynamic nature of the oxidative insult often impairs their full protective capacity or overwhelms the defense mechanisms they regulate, leading to a functional failure in restoring redox balance