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Pernicious anemia is an autoimmune condition in which the bodys immune system attacks the parietal cells in the stomach lining, destroying their ability to produce intrinsic factor

GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

A Reliable Option for Injections For patients who require ongoing injectable supplementation, the Sandoz Vitamin B12 Injectable Solution 1000 mcg/10 mL offers a trusted and convenient choice

Slonim, A.E., Borum, P.R., Tanaka, K., et al., Dietary dependent carnitine deficiency as a cause of nonketotic hypoglycemia in an infant, J