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Description
208 The complexes form stable monofunctional adducts with duplex DNA, 209,210 which bend the DNA backbone axis toward the minor groove

Thus, the impairment of GSH uptake by mitochondria may be important to sensitize invasive cancer cells to prooxidant compounds capable of activating the cell death mechanism

PLoS ONE 5 , e15447 (2010)
Thus, available studies support the notion that superoxide radical produced by the mitochondrial electron transport chain can cause mild uncoupling of mitochondria by activating the membrane proton conductance by uncoupling proteins (UCPs)