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rs72613567 variant in HSD17B13 is an insertion mutation, wherein the Adenine nucleotide gets incorporated next to thymine present at the donor splice site of exon 6 (TTA)

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Furthermore, brain organoids and three-dimensional culture models are employed for high-throughput drug screening because they can replicate the networks involved in iron metabolism in the human brain (Aldewachi et al., 2021)
