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Furthermore, radioresistance and damage to normal brain tissue from radiotherapy, coupled with chemotherapy limitations including poor blood-brain barrier (BBB) penetration, drug resistance, and significant side effects, collectively reduce overall treatment efficacy [7]

Decide whether to continue, adjust, or complete the protocol

Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

This sustained elevation in serotonin levels induces neurochemical and neurophysiological adaptationssuch as desensitization of 5-HT1A autoreceptorswhich enhance the clinical antidepressant effect after several weeks of treatment (Cipriani et al., 2018
