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Iron Homeostasis and Ferroptosis Susceptibility in Alzheimers and Parkinsons Disease Iron dyshomeostasis is increasingly recognized as a significant contributor to AD pathogenesis, with multiple lines of evidence showing disrupted iron regulation in affected brain regions, particularly those crucial for memory and cognition [111]

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RMT is restricted to regions of high receptor density such as the microvascular endothelium of the cerebral cortex and basal ganglia