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Thyroid hormone receptor- agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

The interaction between cells and microenvironment may induce metabolic reprogramming, thus affecting the prognosis

However, several studies in both animal models 14 and humans, 15 have shown no benefit on either activity, or even on muscle LC content in normal individuals

Expansion of BMAT with caloric restriction can be blunted by overexpressing Wnt10b specifically in osteoblast lineage cells, likely by inhibiting the differentiation of skeletal progenitor cells into adipocytes (90)