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One study demonstrated that apatinib inhibited the expression of GLS1, activated the GCN2/eIF2/ATF4 pathway, and promoted the expression of SLC1A5, thereby reprogramming Gln metabolism in NSCLC and weakening the response of tumor cells to apatinib (33)
7 Translational and clinical implications The conceptual framework of redox endophenotypes holds significant translational potential for redefining IMI in clinical practice
Figure 45-1 General mechanisms of digestion and absorption
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