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(Lardizabalaceae) on glucose uptake, using insulin-resistant HepG2 cells as a model
Upon assembly, the inflammasome activates caspase-1, which cleaves gasdermin D (GSDMD) and promotes the maturation and release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and IL-18 ( Figure 2A ) (61)
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Without enough receptors, even lots of GH in the bloodstream has limited impact on that specific tissue
