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The recurring episodes of oxidative stress and intermittent hypoxia associated with OSA contribute to endothelial dysfunction, metabolic dysregulation, systemic inflammation, and an increased risk of cardiovascular complications

After culture for 40 h, cells were collected and lysed in 8 ml of hypotonic buffer (10 mM HEPES pH 8.0, 10 mM KOAc, 1.5 mM Mg(OAc) 2 , 2% (v/v) glycerol, 5 mM NDSB-256 and 0.5 mM TCEP, with 1 tablet of cOmplete Mini EDTA-free Protease Inhibitor Cocktail (Roche, 11873580001) per 10 ml of buffer) by a Dounce homogenizer

Activating ferroptosis could be an effective solution to treat certain kinds of tumors and overcome drug resistance to tumor treatments

Daniell, and Yangs coauthors on the paper, all from Penn Dental Medicine, were first author Jiyoung Park, Guangqi Yan, Kwang-Chul Kwon, Min Liu, and Patricia A