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In the end, this can hold a general counteracting potential and contributing innate neurotransmitter potential, matching with the original cytoprotection concept perception holding equal cell protection (necrosis prevention) against a variety of different agents, thus, a pleiotropic beneficial effects that should be obtained with cytoprotective agents application that could also have neurotransmitter background as well

Interruption of the arterial blood flow due to mechanical pressure and increased subfascial tension caused by muscular edema appeared to combine with the already anoxic state produced in the muscles by the carbon monoxide to produce the muscle necrosis

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