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DSIP works by modulating the hypothalamic-pituitary axis to increase the proportion of deep, restorative slow-wave sleep, during which muscle relaxation is greatest

21 Further research is under way to evaluate this as a predictable therapy (Figs

Moreover, no signs of inflammation were observed in nasal mucosa of co-modified-BM-loaded PLGA-treated mice, suggesting a safe and non-invasive strategy for intranasal delivery 127
