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Proteins involved in mitochondrial and cytosolic iron exchange play a crucial role in regulating erastin-induced ferroptosis: CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET) can inhibit ferroptosis [135], while the BRD7-P53-SLC25A28 axis promotes ferroptosis induction by facilitating mitochondrial iron accumulation and ETC hyperfunction [139]

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This transfer of electrons along the electron transport chain is coupled with the transport of protons across the inner membrane, establishing the electrochemical gradient that generated ATP [42]

doi: 10.1084/jem.20230903 29 MaudeSLLaetschTWBuechnerJRivesSBoyerMBittencourtHet al