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Notably, specific sHSPs have evolved to partner with the HSP70 machinery directly

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Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues

VEGF is involved in hypoxia regeneration and angiogenesis, and the upregulation of hypoxia-related proteins may be intimately associated with the reduced adaptation mechanisms of muscle tissues to decreased blood supply in DM patients