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MMPs are a family of at least 28 zinc-dependent endopeptidases capable of degrading all ECM components, including collagens, non-collagenous proteins, and proteoglycans (Rose and Kooyman, 2016)
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Pasello et al reported that this agent effectively reversed cisplatin resistance in osteosarcoma, alluding toward potentially improved clinical outcomes when using a combination of NBDHEX and cisplatin
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