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Mitochondria mass is low in mouse substantia nigra dopamine neurons

Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm

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For example, Atmrs 2-1 and Atmrs 24 in Arabidopsis , along with their homologues in rice and soybean, increase expression under salt and drought stress, supporting improved Mg absorption and maintaining photosynthetic function ( WRKY, MYB , and bZIP , which in turn regulate MRS 2/MGT gene expression