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Nutrients 13 (10), 3637

Dietary antioxidants and Parkinsons disease

Specifically, there was an increase in the endoplasmic-reticulum-to-cytoplasm Zip7 mRNA and protein expression as well as phosphorylation, leading to elevated intracellular free zinc levels

Although it is beyond the scope of this study to identify the mechanisms by which PDF leads to the activity-dependent (TTX-sensitive) upregulation of CLK/CYC-transcription, we speculate that Ca 2+ influx downstream of PDF/PDFR signalling leads to an upregulation of clock gene transcription
