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Unlike the well-studied CagriSema combination (cagrilintide + semaglutide) with proven 15-25% weight loss results from Phase 3 trials, adding cagrilintide to tirzepatide remains completely unstudied

Furthermore, the relative nephrotoxicity is usually assessed by insensitive techniques, such as blood urea nitrogen, serum creatinine, and enzymuria, that do not give a quantitative representation of the extent of renal injury