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Different classes of flavonoids possess distinct structural features, resulting in variations in their metabolic pathways and bioavailability within the body ( 3 The regulatory effect of flavonoids on immune cells 3.1 Macrophages Macrophages are a type of innate immune cells with phagocytic and antigen-presenting functions, playing a crucial role in various diseases ( NLRP3 inflammasome is a multiprotein complex existing in macrophages linked to a number of chronic inflammatory diseases

Mutations in KEAP1 or NRF2 lead to metabolic rewiring of tumors toward increased glutamine consumption for GSH synthesis (Romero et al., 2017

Mechanistic studies showed that EGCG activated PI3K/Akt pro-survival signaling and suppressed the MAPK pathway, thereby reducing neuroinflammation and neuronal apoptosis

Ferroptosis and cuproptposis in kidney diseases: dysfunction of cell metabolism [J]