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We observed that the extracellular acidification rate (ECAR) increased in GSCs compared with DGCs (Figure 2C), reflecting higher levels of glycolysis, glycolytic capacity, and glycolytic reserve compared with DGCs (Figure 2D)

One other mechanism through which vitamin D may reduce oxidative stress is through its iron regulatory function as it acts on hepcidin and ferroportin which are involved in the intestinal absorption of iron [118,126]

At six months and one year, the PRP was superior in reducing pain levels and improving function

They also recruit epigenetic writers, like histone-modifying enzymes and methyltransferases, to modulate DNA and m 6 A methylation and histone modifications, influencing key signaling pathways associated with therapeutic resistance