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The timing of these peptides would theoretically align with supporting the endogenous melatonin rise that occurs in the evening hours, though specific timing protocols for these peptides have not been established in clinical research

Synthetic DSIP and analogs are used in research to explore sleep architecture, stress-axis regulation, and neuroendocrine signaling

Therefore, Pt-based inorganic nanosystems for tumor-specific delivery provide a prospective strategy to delay and even avoid the PIPN via reducing the accumulation of Pt drug in the peripheral nervous system

Limited research is available regarding its safety during pregnancy, and unnecessary treatment may pose health risks for both the mother and the baby