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Besides c-Met inhibitors, many new therapeutic strategies have been developed, such as the use of miRNAs to regulate HGF/c-Met signaling pathways to inhibit liver cancer progression, targeting endocytosis and more downstream molecules, Hic-5 as a therapeutic strategy to reduce side effects of c-Met inhibitors, as well as herbal treatments

H J Belgers, S Fransen, E M von Meijenfeldt, M N Sosef (Department of Surgery, Atrium Medical Centre, Heerlen)

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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured cu+ Supplants entropically favoured zn 2+ to form cu 4+ Clusters under physiological conditions