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Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation

All but ulongamide F ( 306 ) demonstrated moderate cytotoxic activity against KB and LoVo cells (Luesch et al

Results PTM-dependent ligandability profiling in human cells To investigate changes in protein ligandability as a function of phosphorylation status, we aimed to broadly perturb phosphorylation while minimizing potential convoluting proteomic alterations

Therefore, cancer cells may be more susceptible to ALT activation due to the binding of epitalon to the already reduced levels of histone H1, whereas normal cells may be more resilient as they naturally express higher levels of H1
