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These benefits are valuable as chronic inflammation and oxidative damage have been linked to aging and reduced tissue repair

Among several NO-releasing prodrugs O 2 -(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) 4 has undergone trials in several animals models and shown promise as a novel prodrug in cancer chemotherapy 5

Finally, Basile et al [42] demonstrated that, in type 2 diabetes, CELA3B , which encodes pancreatic elastase (PE), is upregulated in pancreatic acinar cells and the active form of PE is present in the islet microenvironment

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