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A recent data science evidence-based approach to determine the top ten ingredients in oral skin supplements (from 71,000 dietary ingredients of which 1781 were found to have at least one skin-related publication assessed in human clinical trials) found that collagen had the most published human skin health-related data, followed by specific antioxidants (especially from natural sources or products) [25]

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Antioxidant defense research also employs Glutathione, the primary endogenous cellular antioxidant, for investigating oxidative stress protection through thiol-dependent redox mechanisms

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