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Preclinical studies suggest potential roles in soft-tissue repair, gut barrier support, angiogenesis, and neuroprotection

Bar et al., 2022)

52 Reciprocally, inflammageing leads to chronic, continuous generation of inflammatory factors that exhausts the adaptive immune responses, culminating with immunosenescence

Combination of antiviral and immune modulatory therapies Combinations of antiviral therapy targeting multiple steps in the HBV life cycle to suppress viral replication and viral antigen production and immune modulatory therapy to restore immune response to HBV will likely be needed to achieve the goal of HBV "cure," but which specific combination of agents will be needed is not certain because most antiviral or immune modulatory drugs in clinical evaluation are entering either phase Ib or phase II trials at this time