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In agreement, deletion of GPX4 in HT1080 cells was accompanied by a reduction in survival and the appearance of ferroptosis-associated rounding of a fraction of the cells 31 (see also Supplementary Fig

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2019) are expressed in murine astrocytes and contribute to the remarkable ability of these brain cells to efficiently detoxify applied peroxides with halftimes in the minute range (Dringen and Hamprecht 1997

)) with respect to the network parameters End for Where the argmax function determines the state-action pair of highest Q value by considering the quality of all possible actions for a given patient, defined by patient variables n