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In addition to binding bile acids, FXR have been shown to bind polyunsaturated fatty acids (PUFA) such as the omega-3 PUFA docosahexaenoic acid (DHA) and -linolenic acid (ALA)

Tara Oceans: towards global ocean ecosystems biology

Therapeutic Perspectives and Challenges Although most therapeutic approaches put to test against LC have targeted symptom alleviation [307], a comprehensive evaluation of symptoms and clinical signs of affected patients is imperative, in order to timely recognize red flag features pointing towards underlying objective systemic disorders that are likely to have a decisive impact on patient prognosis
