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The aging process is marked by a gradual yet progressive decline in the functional capacity of multiple organs, impairing their ability to sustain baseline tissue homeostasis and adequately respond to physiological demands under stress ( 3.5 Chemotherapy-induced renal injury 3.5.1 Cisplatin-induced nephrotoxicity Cisplatin (CP) is a prominent chemotherapeutic agent utilized in the treatment of solid tumors (Malaviya, 2016)

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In addition, extending the studies about their mechanisms of action for inducing allergic inflammation is necessary to improve our knowledge of allergy pathophysiology and to discover other options of allergy treatment

MOR-mediated inhibition of GABA input is more sensitive than that of postsynaptic hyperpolarization, suggesting there may be opioid peptide concentration-dependent local circuit dynamics at play (Pennock and Hentges, 2011)