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Novo Nordisk filed for FDA approval of CagriSema in early 2026, with a review decision expected later this year
Functional analysis demonstrated that miR-491-5p overexpression exerted a tumor suppressor effect by targeting IGF2, and this was also confirmed by the negative correlation between miRNA levels and IGF2 mRNA and protein levels in CRC tissues and cell lines
doi: 10.1016/j.cbi.2006.03.007
Fernndez-Sarmiento et al
