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Interestingly, the phosphodiesterase inhibitor Cilostazol (used in peripheral vascular disease treatment) is able to improve cognitive function in mice by increasing the hippocampal production of IGF-I through stimulation of sensory neurons [350]

As highlighted by this review, the complex pathophysiology and heterogeneous ASD phenotype are hypothesized, for some individuals with ASD, to be related to the deregulation of the immune system