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These compounds are classified as NDBs and have unique physical, chemical, and mechanical properties, which are exploited in biomedical applications

Vitamin B12 is a water-soluble vitamin, meaning it dissolves easily in water and is not stored by the body

Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

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