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The rationale was that direct delivery to the joint would maximize local efficacy while minimizing systemic exposure

NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

Also, mice carrying a genetic mutation that lack one of the igf1r alleles ( igf1r +/ ) show a 10 % reduction in post-natal growth, insulin resistance and glucose intolerance [237]
