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distinguished five different subtypes of mCRPC based on RNA expression of AR and the most common neuroendocrine markers: AR-high tumors (ARPC), AR-low tumors (ARLPC), amphicrine tumors with both the expression of AR and NE markers (AMPC), double-negative tumors (DNPC), and tumors with small cell and NE features without AR expression (SCNPC) [40]

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(Ed.), Uptodate