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The exclusion criteria were as follows: pregnancy, lactation, menopause

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

doi: 10.3389/fcimb.2024.1337223 66 SwinkelsM.RijkersM.VoorbergJ.VidarssonG.LeebeekF

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