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Rather than interacting with receptors on the plasma membrane of their target cells, the gasotransmitters (soluble gases such as nitric oxide and carbon monoxide, as unconventional neurotransmitters) can cross the cell membrane and act directly on molecules inside the cell [36]

74 The enhanced oxidant stress in the mitochondrial matrix is then mainly derived from complex I and, to a lesser degree, from complex III, 71 and the oxidant stress and injury correlate with protein adduct formation in mitochondria

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SOD1, extracellular superoxide dismutase